| 2017-08-05 00:00:0005/08/17 | Guisborough Town V Stockton Town | 4 - 2 | | 2017-18 | | FA CupExtra Preliminary Round Qualifying | |
| 2017-08-08 00:00:0008/08/17 | West Auckland Town V Guisborough Town | 9 - 0 | Division 1 | 2017-18 | | | |
| 2017-08-12 00:00:0012/08/17 | Newton Aycliffe V Guisborough Town | 3 - 3 | Division 1 | 2017-18 | | | |
| 2017-08-16 00:00:0016/08/17 | Guisborough Town V Consett | 0 - 2 | Division 1 | 2017-18 | | | |
| 2017-08-19 00:00:0019/08/17 | Guisborough Town V Shildon | 1 - 5 | | 2017-18 | | FA CupPreliminary Round Qualifying | |
| 2017-08-24 00:00:0024/08/17 | Newcastle Benfield V Guisborough Town | 4 - 2 | Division 1 | 2017-18 | | | |
| 2017-08-26 00:00:0026/08/17 | Bishop Auckland V Guisborough Town | 2 - 4 | Division 1 | 2017-18 | | | |
| 2017-08-30 00:00:0030/08/17 | Guisborough Town V Dunston UTS | 2 - 3 | Division 1 | 2017-18 | | | |
| 2017-09-02 00:00:0002/09/17 | Penrith V Guisborough Town | 4 - 1 | Division 1 | 2017-18 | | | |
| 2017-09-06 00:00:0006/09/17 | Guisborough Town V Stockton Town | 3 - 2 | Division 1 | 2017-18 | | | |
| 2017-09-09 00:00:0009/09/17 | Ryhope CW V Guisborough Town | 7 - 1 | | 2017-18 | | FA VaseFirst Qualifying Round | |
| 2017-09-16 00:00:0016/09/17 | Guisborough Town V North Shields | 0 - 2 | Division 1 | 2017-18 | | | |
| 2017-09-23 00:00:0023/09/17 | Guisborough Town V Morpeth Town | 2 - 2 | Division 1 | 2017-18 | | | |
| 2017-09-30 00:00:0030/09/17 | Guisborough Town V Billingham Synthonia | 3 - 0 | Division 1 | 2017-18 | | | |
| 2017-10-07 00:00:0007/10/17 | Team Northumbria V Guisborough Town | 3 - 2 | Division 1 | 2017-18 | | | |
| 2017-10-14 00:00:0014/10/17 | Guisborough Town V Sunderland RCA | 3 - 4 | Division 1 | 2017-18 | | | |
| 2017-10-18 00:00:0018/10/17 | Guisborough Town V Whitley Bay | 2 - 1 | Division 1 | 2017-18 | | | |
| 2017-10-21 00:00:0021/10/17 | Shildon V Guisborough Town | 4 - 2 | Division 1 | 2017-18 | | | |
| 2017-10-28 00:00:0028/10/17 | Guisborough Town V Jarrow Roofing BCA | 4 - 2 | Division 1 | 2017-18 | | | |
| 2017-11-04 00:00:0004/11/17 | Washington V Guisborough Town | 0 - 4 | Division 1 | 2017-18 | | | |
| 2017-11-11 00:00:0011/11/17 | Guisborough Town V Ashington | 1 - 1 | Division 1 | 2017-18 | | | |
| 2017-11-15 00:00:0015/11/17 | Guisborough Town V Northallerton Town | 4 - 4 | | 2017-18 | | Brooks Mileson Memorial League CupSecond Round | |
| 2017-11-18 00:00:0018/11/17 | Guisborough Town V Bishop Auckland | 2 - 1 | Division 1 | 2017-18 | | | |
| 2017-11-25 00:00:0025/11/17 | Guisborough Town V Seaham Red Star | 1 - 0 | Division 1 | 2017-18 | | | |
| 2017-12-06 00:00:0006/12/17 | Guisborough Town V Boro Rangers | 1 - 2 | | 2017-18 | | North Riding Senior CupFirst Round | |
| 2017-12-16 00:00:0016/12/17 | Consett V Guisborough Town | 3 - 2 | Division 1 | 2017-18 | | | |
| 2017-12-20 00:00:0020/12/17 | Stockton Town V Guisborough Town | 2 - 1 | Division 1 | 2017-18 | | | |
| 2017-12-23 00:00:0023/12/17 | Guisborough Town V Newcastle Benfield | 0 - 4 | Division 1 | 2017-18 | | | |
| 2017-12-30 00:00:0030/12/17 | Guisborough Town V Penrith | 1 - 2 | Division 1 | 2017-18 | | | |
| 2018-01-13 00:00:0013/01/18 | Guisborough Town V Newton Aycliffe | 1 - 1 | Division 1 | 2017-18 | | | |
| 2018-01-17 00:00:0017/01/18 | Guisborough Town V West Auckland Town | 1 - 1 | Division 1 | 2017-18 | | | |
| 2018-01-20 00:00:0020/01/18 | Whitley Bay V Guisborough Town | 2 - 2 | Division 1 | 2017-18 | | | |
| 2018-01-24 00:00:0024/01/18 | Bishop Auckland V Guisborough Town | 3 - 2 | | 2017-18 | | Brooks Mileson Memorial League CupThird Round | |
| 2018-01-27 00:00:0027/01/18 | Ashington V Guisborough Town | 2 - 2 | Division 1 | 2017-18 | | | |
| 2018-02-03 00:00:0003/02/18 | North Shields V Guisborough Town | 2 - 3 | Division 1 | 2017-18 | | | |
| 2018-02-10 00:00:0010/02/18 | Ryhope CW V Guisborough Town | 0 - 3 | Division 1 | 2017-18 | | | |
| 2018-02-16 00:00:0016/02/18 | Billingham Synthonia V Guisborough Town | 1 - 1 | Division 1 | 2017-18 | | | |
| 2018-02-24 00:00:0024/02/18 | Guisborough Town V Team Northumbria | 2 - 1 | Division 1 | 2017-18 | | | |
| 2018-03-24 00:00:0024/03/18 | Guisborough Town V Washington | 0 - 3 | Division 1 | 2017-18 | | | |
| 2018-04-14 00:00:0014/04/18 | Seaham Red Star V Guisborough Town | 1 - 3 | Division 1 | 2017-18 | | | |
| 2018-04-16 00:00:0016/04/18 | Morpeth Town V Guisborough Town | 1 - 1 | Division 1 | 2017-18 | | | |
| 2018-04-18 00:00:0018/04/18 | Guisborough Town V Shildon | 1 - 0 | Division 1 | 2017-18 | | | |
| 2018-04-21 00:00:0021/04/18 | Guisborough Town V Ryhope CW | 2 - 1 | Division 1 | 2017-18 | | | |
| 2018-04-24 00:00:0024/04/18 | Jarrow Roofing BCA V Guisborough Town | 0 - 2 | Division 1 | 2017-18 | | | |
| 2018-04-28 00:00:0028/04/18 | Sunderland RCA V Guisborough Town | 3 - 0 | Division 1 | 2017-18 | | | |
| 2018-05-02 00:00:0002/05/18 | Marske United V Guisborough Town | 1 - 0 | Division 1 | 2017-18 | | | |
| 2018-05-05 15:00:0005/05/18 | Dunston UTS V Guisborough Town | 1 - 0 | Division 1 | 2017-18 | The UTS Stadium | | |
| 2018-05-07 12:00:0007/05/18 | Guisborough Town V Marske United | 1 - 1 | Division 1 | 2017-18 | King George V Ground | | |
