| 2021-07-31 15:00:0031/07/21 | Carlisle City v Billingham Synthonia | 4 - 2 | Division 2 | 2021-22 | Gillford Park Stadium | | 81 |
| Samuel Jackson (4) Dan Kirkup (7) Jordan Palmer (46) Nathan Johnstone (84) |
| Kurtis Howes 2 (54, 75) |
| 2021-08-04 19:45:0004/08/21 | Jarrow v Carlisle City | 2 - 1 | Division 2 | 2021-22 | Perth Green CA | | 135 |
| Channon North (2) Jason Blackburn (33) |
| Samuel Atkinson (77) |
| 2021-08-07 15:00:0007/08/21 | Heaton Stannington v Carlisle City | 2 - 2 | Division 2 | 2021-22 | Grounsell Park | | 160 |
| Jay Hornsby (66) James Proctor (86) |
| Jordan Palmer 2 (64, 88 pen) |
| 2021-08-10 19:45:0010/08/21 | Carlisle City v Sunderland West End | 2 - 1 | Division 2 | 2021-22 | Gillford Park Stadium | | 105 |
| Tyler Bowman (29) Aaron Bradbury (76 pen) |
| James Armstrong (90) |
| 2021-08-14 15:00:0014/08/21 | Carlisle City v Brandon United | 3 - 1 | Division 2 | 2021-22 | Gillford Park Stadium | | 81 |
| Liam Studholme 2 (5, 54) Dan Kirkup (9) |
| Kai Hewitson (71), Reese Brown sent off (73) |
| 2021-08-18 19:45:0018/08/21 | Ryton & Crawcrook Albion v Carlisle City | 4 - 0 | Division 2 | 2021-22 | Kingsley Park | | 80 |
| Andrew Brown (7) Joe Thompson (14) Dillon Blake 2 (18, 25), Blake missed pen (25) |
| 2021-08-21 15:00:0021/08/21 | Easington Colliery v Carlisle City | 3 - 0 | Division 2 | 2021-22 | Welfare Park | | 73 |
| Kevin Pearn 2 (22, 59) Dylan Elliott (55) |
| 2021-08-28 15:00:0028/08/21 | Carlisle City v Newcastle University | 4 - 1 | Division 2 | 2021-22 | Gillford Park Stadium | | 95 |
| Jordan Irving (18), Jordan Palmer (21), Josh Simpson (56), Jordan Irving (71) |
| James Coates (76) |
| 2021-08-31 19:45:0031/08/21 | Carlisle City v Tow Law Town | 1 - 0 | Division 2 | 2021-22 | Gillford Park Stadium | | 97 |
| Aaron Bradbury (20 pen) |
| 2021-09-04 15:00:0004/09/21 | Birtley Town v Carlisle City | 2 - 5 | Division 2 | 2021-22 | The Arrowmark Home Improvements Stadium | | 143 |
| Joe Barwick (14) Kaleb Young (19) |
| Jordan Irving (12) Jordan Holt (15) Josh Simpson (22) Jordan Palmer (27) Dan Kirkup (40) |
| 2021-09-11 15:00:0011/09/21 | Carlisle City v Guisborough Town | 1 - 0 | | 2021-22 | Gillford Park Stadium | FA VaseFirst Round Qualifying | 146 |
| Jordan Holt (64) |
| Robert Dean sent off (45) |
| 2021-09-14 19:45:0014/09/21 | Carlisle City v Boldon CA | 1 - 1 | Division 2 | 2021-22 | Gillford Park Stadium | | 98 |
| Dan Kirkup (3) |
| Levi Collins (32) |
| 2021-09-18 15:00:0018/09/21 | Carlisle City v Washington | 6 - 0 | Division 2 | 2021-22 | Gillford Park Stadium | | 122 |
| Jordan Irving (4) Jordan Palmer (8) Sam Atkinson (15) Brandon Longcake (69) Niall Seymour (og 70) Jordan Holt (73) |
| 2021-09-25 15:00:0125/09/21 | Carlisle City v Esh Winning | 4 - 1 | | 2021-22 | Gillford Park Stadium | FA VaseSecond Round Qualifying | 93 |
| Samuel Atkinson (20) Jordan Irving 3 (58, 75, 77) |
| Jamie McLeod (12 pen) |
| 2021-09-28 19:45:0028/09/21 | Redcar Town v Carlisle City | 1 - 1 | Division 2 | 2021-22 | The Vibrant Stadium | | 48 |
| Sam Webster (17) |
| Jordan Palmer (60), Palmer missed pen (60) |
| 2021-10-02 15:00:0002/10/21 | Blyth Town v Carlisle City | 0 - 5 | Division 2 | 2021-22 | Gateway Park | | 177 |
| Samuel Atkinson (22) Keighran Kerr (35) Jordan Palmer (56) Jordan Irvine (76 pen) Nathan Johnstone (93) |
| 2021-10-16 15:00:0016/10/21 | Horden CW v Carlisle City | 15:00:003:00 pm | Division 2 | 2021-22 | Horden Community Welfare Park | | |
| 2021-10-23 15:00:1623/10/21 | Carlisle City v Chester-le-Street | 15:00:163:00 pm | | 2021-22 | Gillford Park Stadium | FA VaseFirst Round | |
| 2021-10-30 15:00:0030/10/21 | Chester-le-Street v Carlisle City | 15:00:003:00 pm | Division 2 | 2021-22 | Moor Park | | |
| 2021-11-02 19:45:0002/11/21 | Carlisle City v Durham City | 19:45:007:45 pm | Division 2 | 2021-22 | Gillford Park Stadium | | |
| 2021-11-06 15:00:0006/11/21 | Carlisle City v Jarrow | 15:00:003:00 pm | Division 2 | 2021-22 | Gillford Park Stadium | | |
| 2021-11-13 15:00:0013/11/21 | Sunderland West End v Carlisle City | 15:00:003:00 pm | Division 2 | 2021-22 | Ford Hub Sports Complex | | |
| 2021-11-20 15:00:0020/11/21 | Carlisle City v Ryton & Crawcrook Albion | 15:00:003:00 pm | Division 2 | 2021-22 | Gillford Park Stadium | | |
| 2021-11-27 15:00:0027/11/21 | Carlisle City v Bedlington Terriers | 15:00:003:00 pm | Division 2 | 2021-22 | Gillford Park Stadium | | |
| 2021-12-04 15:00:0004/12/21 | Tow Law Town v Carlisle City | 15:00:003:00 pm | Division 2 | 2021-22 | Ironworks Road | | |
| 2021-12-11 15:00:0011/12/21 | Carlisle City v Willington | 15:00:003:00 pm | Division 2 | 2021-22 | Gillford Park Stadium | | |
| 2021-12-18 15:00:0018/12/21 | Boldon CA v Carlisle City | 15:00:003:00 pm | Division 2 | 2021-22 | Boldon Colliery Welfare Ground | | |
| 2022-01-08 15:00:0008/01/22 | Durham City v Carlisle City | 15:00:003:00 pm | Division 2 | 2021-22 | Hall Lane | | |
| 2022-01-15 15:00:0015/01/22 | Carlisle City v Redcar Town | 15:00:003:00 pm | Division 2 | 2021-22 | Gillford Park Stadium | | |
| 2022-01-22 15:00:0022/01/22 | Billingham Synthonia v Carlisle City | 15:00:003:00 pm | Division 2 | 2021-22 | Norton (Teesside) Sports Complex | | |
| 2022-01-29 15:00:0029/01/22 | Carlisle City v Heaton Stannington | 15:00:003:00 pm | Division 2 | 2021-22 | Gillford Park Stadium | | |
| 2022-02-05 15:00:0005/02/22 | Brandon United v Carlisle City | 15:00:003:00 pm | Division 2 | 2021-22 | Welfare Ground | | |
| 2022-02-12 15:00:0012/02/22 | Carlisle City v Easington Colliery | 15:00:003:00 pm | Division 2 | 2021-22 | Gillford Park Stadium | | |
| 2022-02-19 15:00:0019/02/22 | Newcastle University v Carlisle City | 15:00:003:00 pm | Division 2 | 2021-22 | Kimberley Park | | |
| 2022-02-26 15:00:0026/02/22 | Carlisle City v Birtley Town | 15:00:003:00 pm | Division 2 | 2021-22 | Gillford Park Stadium | | |
| 2022-03-05 15:00:0005/03/22 | Carlisle City v Esh Winning | 15:00:003:00 pm | Division 2 | 2021-22 | Gillford Park Stadium | | |
| 2022-03-12 15:00:0012/03/22 | Washington v Carlisle City | 15:00:003:00 pm | Division 2 | 2021-22 | Ford Hub Sports Complex | | |
| 2022-03-19 15:00:0019/03/22 | Carlisle City v Blyth Town | 15:00:003:00 pm | Division 2 | 2021-22 | Gillford Park Stadium | | |
| 2022-03-26 15:00:0026/03/22 | Bedlington Terriers v Carlisle City | 15:00:003:00 pm | Division 2 | 2021-22 | Doctor Pit Park | | |
| 2022-03-30 19:45:0030/03/22 | Willington v Carlisle City | 19:45:007:45 pm | Division 2 | 2021-22 | Hall Lane | | |
| 2022-04-02 15:00:0002/04/22 | Carlisle City v Horden CW | 15:00:003:00 pm | Division 2 | 2021-22 | Gillford Park Stadium | | |
| 2022-04-09 15:00:0009/04/22 | Esh Winning v Carlisle City | 15:00:003:00 pm | Division 2 | 2021-22 | The WindowsPlusRoofs Arena | | |
| 2022-04-16 15:00:0016/04/22 | Carlisle City v Chester-le-Street | 15:00:003:00 pm | Division 2 | 2021-22 | Gillford Park Stadium | | |
