| 2021-07-31 15:00:0031/07/21 | Carlisle City v Billingham Synthonia | 4 - 2 | Division 2 | 2021-22 | Gillford Park Stadium | | 81 |
| Samuel Jackson (4) Dan Kirkup (7) Jordan Palmer (46) Nathan Johnstone (84) |
| Kurtis Howes 2 (54, 75) |
| 2021-08-04 19:30:0004/08/21 | Billingham Synthonia v Washington | 19:30:007:30 pm | Division 2 | 2021-22 | Norton (Teesside) Sports Complex | | |
| 2021-08-07 15:00:0007/08/21 | Billingham Synthonia v Tow Law Town | 15:00:003:00 pm | Division 2 | 2021-22 | Norton (Teesside) Sports Complex | | |
| 2021-08-11 19:30:0011/08/21 | Blyth Town v Billingham Synthonia | 19:30:007:30 pm | Division 2 | 2021-22 | Gateway Park | | |
| 2021-08-14 15:00:0014/08/21 | Willington v Billingham Synthonia | 15:00:003:00 pm | Division 2 | 2021-22 | Hall Lane | | |
| 2021-08-18 19:30:0018/08/21 | Billingham Synthonia v Bedlington Terriers | 19:30:007:30 pm | Division 2 | 2021-22 | Norton (Teesside) Sports Complex | | |
| 2021-08-21 15:00:0021/08/21 | Billingham Synthonia v Boldon CA | 15:00:003:00 pm | Division 2 | 2021-22 | Norton (Teesside) Sports Complex | | |
| 2021-08-25 19:30:0025/08/21 | Billingham Synthonia v Horden CW | 19:30:007:30 pm | Division 2 | 2021-22 | Norton (Teesside) Sports Complex | | |
| 2021-08-28 15:00:0028/08/21 | Billingham Synthonia v Durham City | 15:00:003:00 pm | Division 2 | 2021-22 | Norton (Teesside) Sports Complex | | |
| 2021-09-01 19:30:0001/09/21 | Billingham Synthonia v Esh Winning | 19:30:007:30 pm | Division 2 | 2021-22 | Norton (Teesside) Sports Complex | | |
| 2021-09-04 15:00:0004/09/21 | Billingham Synthonia v Redcar Town | 15:00:003:00 pm | Division 2 | 2021-22 | Norton (Teesside) Sports Complex | | |
| 2021-09-07 19:30:0007/09/21 | Chester-le-Street v Billingham Synthonia | 19:30:007:30 pm | Division 2 | 2021-22 | Moor Park | | |
| 2021-09-11 15:00:0011/09/21 | Whitley Bay v Billingham Synthonia | 15:00:003:00 pm | | 2021-22 | Hillheads Park | FA VaseFirst Round Qualifying | |
| 2021-09-15 19:30:0015/09/21 | Billingham Synthonia v Jarrow | 19:30:007:30 pm | Division 2 | 2021-22 | Norton (Teesside) Sports Complex | | |
| 2021-09-22 19:30:0022/09/21 | Sunderland West End v Billingham Synthonia | 19:30:007:30 pm | Division 2 | 2021-22 | Ford Hub Sports Complex | | |
| 2021-09-29 19:30:0029/09/21 | Billingham Synthonia v Ryton & Crawcrook Albion | 19:30:007:30 pm | Division 2 | 2021-22 | Norton (Teesside) Sports Complex | | |
| 2021-10-02 15:00:0002/10/21 | Billingham Synthonia v Heaton Stannington | 15:00:003:00 pm | Division 2 | 2021-22 | Norton (Teesside) Sports Complex | | |
| 2021-10-09 15:00:0009/10/21 | Brandon United v Billingham Synthonia | 15:00:003:00 pm | Division 2 | 2021-22 | Welfare Ground | | |
| 2021-10-16 15:00:0016/10/21 | Billingham Synthonia v Easington Colliery | 15:00:003:00 pm | Division 2 | 2021-22 | Norton (Teesside) Sports Complex | | |
| 2021-10-23 15:00:0023/10/21 | Newcastle University v Billingham Synthonia | 15:00:003:00 pm | Division 2 | 2021-22 | Kimberley Park | | |
| 2021-10-30 15:00:0030/10/21 | Billingham Synthonia v Birtley Town | 15:00:003:00 pm | Division 2 | 2021-22 | Norton (Teesside) Sports Complex | | |
| 2021-11-06 15:00:0006/11/21 | Washington v Billingham Synthonia | 15:00:003:00 pm | Division 2 | 2021-22 | Ford Hub Sports Complex | | |
| 2021-11-13 15:00:0013/11/21 | Billingham Synthonia v Blyth Town | 15:00:003:00 pm | Division 2 | 2021-22 | Norton (Teesside) Sports Complex | | |
| 2021-11-20 15:00:0020/11/21 | Bedlington Terriers v Billingham Synthonia | 15:00:003:00 pm | Division 2 | 2021-22 | Doctor Pit Park | | |
| 2021-11-27 15:00:0027/11/21 | Horden CW v Billingham Synthonia | 15:00:003:00 pm | Division 2 | 2021-22 | Horden Community Welfare Park | | |
| 2021-12-04 15:00:0004/12/21 | Esh Winning v Billingham Synthonia | 15:00:003:00 pm | Division 2 | 2021-22 | The WindowsPlusRoofs Arena | | |
| 2021-12-11 15:00:0011/12/21 | Billingham Synthonia v Chester-le-Street | 15:00:003:00 pm | Division 2 | 2021-22 | Norton (Teesside) Sports Complex | | |
| 2021-12-18 15:00:0018/12/21 | Jarrow v Billingham Synthonia | 15:00:003:00 pm | Division 2 | 2021-22 | Perth Green CA | | |
| 2022-01-08 15:00:0008/01/22 | Billingham Synthonia v Sunderland West End | 15:00:003:00 pm | Division 2 | 2021-22 | Norton (Teesside) Sports Complex | | |
| 2022-01-15 15:00:0015/01/22 | Ryton & Crawcrook Albion v Billingham Synthonia | 15:00:003:00 pm | Division 2 | 2021-22 | Kingsley Park | | |
| 2022-01-22 15:00:0022/01/22 | Billingham Synthonia v Carlisle City | 15:00:003:00 pm | Division 2 | 2021-22 | Norton (Teesside) Sports Complex | | |
| 2022-01-29 15:00:0029/01/22 | Tow Law Town v Billingham Synthonia | 15:00:003:00 pm | Division 2 | 2021-22 | Ironworks Road | | |
| 2022-02-05 15:00:0005/02/22 | Billingham Synthonia v Willington | 15:00:003:00 pm | Division 2 | 2021-22 | Norton (Teesside) Sports Complex | | |
| 2022-02-12 15:00:0012/02/22 | Boldon CA v Billingham Synthonia | 15:00:003:00 pm | Division 2 | 2021-22 | Boldon Colliery Welfare Ground | | |
| 2022-02-19 15:00:0019/02/22 | Durham City v Billingham Synthonia | 15:00:003:00 pm | Division 2 | 2021-22 | Hall Lane | | |
| 2022-02-26 15:00:0026/02/22 | Redcar Town v Billingham Synthonia | 15:00:003:00 pm | Division 2 | 2021-22 | The Vibrant Stadium | | |
| 2022-03-19 15:00:0019/03/22 | Heaton Stannington v Billingham Synthonia | 15:00:003:00 pm | Division 2 | 2021-22 | Grounsell Park | | |
| 2022-03-26 15:00:0026/03/22 | Billingham Synthonia v Brandon United | 15:00:003:00 pm | Division 2 | 2021-22 | Norton (Teesside) Sports Complex | | |
| 2022-04-02 15:00:0002/04/22 | Easington Colliery v Billingham Synthonia | 15:00:003:00 pm | Division 2 | 2021-22 | Welfare Park | | |
| 2022-04-09 15:00:0009/04/22 | Billingham Synthonia v Newcastle University | 15:00:003:00 pm | Division 2 | 2021-22 | Norton (Teesside) Sports Complex | | |
| 2022-04-16 15:00:0016/04/22 | Birtley Town v Billingham Synthonia | 15:00:003:00 pm | Division 2 | 2021-22 | The Arrowmark Home Improvements Stadium | | |
