| 2021-07-31 15:00:0031/07/21 | Esh Winning v Birtley Town | 0 - 5 | Division 2 | 2021-22 | The WindowsPlusRoofs Arena | | 103 |
| Nick Marley sent off (32) |
| Lewis Orrell (30) Joe Barwick 3 (47, 63, 80) Robbie Williamson (75) |
| 2021-08-05 19:30:0005/08/21 | Esh Winning v Willington | 19:30:007:30 pm | Division 2 | 2021-22 | The WindowsPlusRoofs Arena | | |
| 2021-08-07 15:00:0007/08/21 | Washington v Esh Winning | 15:00:003:00 pm | Division 2 | 2021-22 | Ford Hub Sports Complex | | |
| 2021-08-10 19:30:0010/08/21 | Boldon CA v Esh Winning | 19:30:007:30 pm | Division 2 | 2021-22 | Boldon Colliery Welfare Ground | | |
| 2021-08-14 15:00:0014/08/21 | Esh Winning v Blyth Town | 15:00:003:00 pm | Division 2 | 2021-22 | The WindowsPlusRoofs Arena | | |
| 2021-08-17 19:30:0017/08/21 | Durham City v Esh Winning | 19:30:007:30 pm | Division 2 | 2021-22 | Hall Lane | | |
| 2021-08-21 15:00:0021/08/21 | Bedlington Terriers v Esh Winning | 15:00:003:00 pm | Division 2 | 2021-22 | Doctor Pit Park | | |
| 2021-08-26 19:30:0026/08/21 | Esh Winning v Redcar Town | 19:30:007:30 pm | Division 2 | 2021-22 | The WindowsPlusRoofs Arena | | |
| 2021-08-28 15:00:0028/08/21 | Esh Winning v Horden CW | 15:00:003:00 pm | Division 2 | 2021-22 | The WindowsPlusRoofs Arena | | |
| 2021-09-01 19:30:0001/09/21 | Billingham Synthonia v Esh Winning | 19:30:007:30 pm | Division 2 | 2021-22 | Norton (Teesside) Sports Complex | | |
| 2021-09-09 19:30:0009/09/21 | Esh Winning v Heaton Stannington | 19:30:007:30 pm | Division 2 | 2021-22 | The WindowsPlusRoofs Arena | | |
| 2021-09-15 19:45:0015/09/21 | Brandon United v Esh Winning | 19:45:007:45 pm | Division 2 | 2021-22 | Welfare Ground | | |
| 2021-09-18 15:00:0018/09/21 | Chester-le-Street v Esh Winning | 15:00:003:00 pm | Division 2 | 2021-22 | Moor Park | | |
| 2021-09-23 19:30:0023/09/21 | Esh Winning v Easington Colliery | 19:30:007:30 pm | Division 2 | 2021-22 | The WindowsPlusRoofs Arena | | |
| 2021-09-30 19:30:0030/09/21 | Newcastle University v Esh Winning | 19:30:007:30 pm | Division 2 | 2021-22 | Kimberley Park | | |
| 2021-10-02 15:00:0002/10/21 | Esh Winning v Jarrow | 15:00:003:00 pm | Division 2 | 2021-22 | The WindowsPlusRoofs Arena | | |
| 2021-10-09 15:00:0009/10/21 | Sunderland West End v Esh Winning | 15:00:003:00 pm | Division 2 | 2021-22 | Ford Hub Sports Complex | | |
| 2021-10-16 15:00:0016/10/21 | Esh Winning v Ryton & Crawcrook Albion | 15:00:003:00 pm | Division 2 | 2021-22 | The WindowsPlusRoofs Arena | | |
| 2021-10-23 15:00:0023/10/21 | Carlisle City v Esh Winning | 15:00:003:00 pm | Division 2 | 2021-22 | Gillford Park Stadium | | |
| 2021-10-30 15:00:0030/10/21 | Esh Winning v Tow Law Town | 15:00:003:00 pm | Division 2 | 2021-22 | The WindowsPlusRoofs Arena | | |
| 2021-11-06 15:00:0006/11/21 | Willington v Esh Winning | 15:00:003:00 pm | Division 2 | 2021-22 | Hall Lane | | |
| 2021-11-13 15:00:0013/11/21 | Esh Winning v Boldon CA | 15:00:003:00 pm | Division 2 | 2021-22 | The WindowsPlusRoofs Arena | | |
| 2021-11-20 15:00:0020/11/21 | Esh Winning v Durham City | 15:00:003:00 pm | Division 2 | 2021-22 | The WindowsPlusRoofs Arena | | |
| 2021-11-27 15:00:0027/11/21 | Redcar Town v Esh Winning | 15:00:003:00 pm | Division 2 | 2021-22 | The Vibrant Stadium | | |
| 2021-12-04 15:00:0004/12/21 | Esh Winning v Billingham Synthonia | 15:00:003:00 pm | Division 2 | 2021-22 | The WindowsPlusRoofs Arena | | |
| 2021-12-11 15:00:0011/12/21 | Heaton Stannington v Esh Winning | 15:00:003:00 pm | Division 2 | 2021-22 | Grounsell Park | | |
| 2021-12-18 15:00:0018/12/21 | Esh Winning v Brandon United | 15:00:003:00 pm | Division 2 | 2021-22 | The WindowsPlusRoofs Arena | | |
| 2022-01-08 15:00:0008/01/22 | Easington Colliery v Esh Winning | 15:00:003:00 pm | Division 2 | 2021-22 | Welfare Park | | |
| 2022-01-15 15:00:0015/01/22 | Esh Winning v Newcastle University | 15:00:003:00 pm | Division 2 | 2021-22 | The WindowsPlusRoofs Arena | | |
| 2022-01-22 15:00:0022/01/22 | Birtley Town v Esh Winning | 15:00:003:00 pm | Division 2 | 2021-22 | The Arrowmark Home Improvements Stadium | | |
| 2022-01-29 15:00:0029/01/22 | Esh Winning v Washington | 15:00:003:00 pm | Division 2 | 2021-22 | The WindowsPlusRoofs Arena | | |
| 2022-02-05 15:00:0005/02/22 | Blyth Town v Esh Winning | 15:00:003:00 pm | Division 2 | 2021-22 | Gateway Park | | |
| 2022-02-12 15:00:0012/02/22 | Esh Winning v Bedlington Terriers | 15:00:003:00 pm | Division 2 | 2021-22 | The WindowsPlusRoofs Arena | | |
| 2022-02-19 15:00:0019/02/22 | Horden CW v Esh Winning | 15:00:003:00 pm | Division 2 | 2021-22 | Horden Community Welfare Park | | |
| 2022-03-12 15:00:0012/03/22 | Esh Winning v Chester-le-Street | 15:00:003:00 pm | Division 2 | 2021-22 | The WindowsPlusRoofs Arena | | |
| 2022-03-19 15:00:0019/03/22 | Jarrow v Esh Winning | 15:00:003:00 pm | Division 2 | 2021-22 | Perth Green CA | | |
| 2022-03-26 15:00:0026/03/22 | Esh Winning v Sunderland West End | 15:00:003:00 pm | Division 2 | 2021-22 | The WindowsPlusRoofs Arena | | |
| 2022-04-02 15:00:0002/04/22 | Ryton & Crawcrook Albion v Esh Winning | 15:00:003:00 pm | Division 2 | 2021-22 | Kingsley Park | | |
| 2022-04-09 15:00:0009/04/22 | Esh Winning v Carlisle City | 15:00:003:00 pm | Division 2 | 2021-22 | The WindowsPlusRoofs Arena | | |
| 2022-04-16 15:00:0016/04/22 | Tow Law Town v Esh Winning | 15:00:003:00 pm | Division 2 | 2021-22 | Ironworks Road | | |
