| 2021-07-31 15:00:0031/07/21 | Tow Law Town v Redcar Town | 2 - 2 | Division 2 | 2021-22 | Ironworks Road | | 101 |
| Michael Brown 2 (36,67) |
| Sean Machin (62) Ryan Bennions (82) |
| 2021-08-03 19:30:0003/08/21 | Chester-le-Street v Tow Law Town | 1 - 1 | Division 2 | 2021-22 | Moor Park | | 182 |
| Michael Hepplewhite (13) |
| Michael Brown (57) |
| 2021-08-07 15:00:0007/08/21 | Billingham Synthonia v Tow Law Town | 3 - 2 | Division 2 | 2021-22 | Norton (Teesside) Sports Complex | | 68 |
| Kurtis Howes 2 (79 pen, 81 pen) David Onions (87) |
| Mason Hurworth (2) Barrie Smith (70 pen) |
| 2021-08-10 19:30:0010/08/21 | Tow Law Town v Jarrow | 3 - 1 | Division 2 | 2021-22 | Ironworks Road | | 148 |
| Thomas McAloon (20) Mason Hurworth (22) Matty Moffat (42) |
| Channon North (35) |
| 2021-08-14 15:00:0014/08/21 | Tow Law Town v Heaton Stannington | 1 - 0 | Division 2 | 2021-22 | Ironworks Road | | 95 |
| Mason Hurworth (68) |
| 2021-08-18 19:30:0018/08/21 | Sunderland West End v Tow Law Town | 3 - 0 | Division 2 | 2021-22 | Ford Hub Sports Complex | | 92 |
| Alex Herring (19) Lewis Charlton (39) Owen Imeson (86 pen) |
| 2021-08-21 15:00:0021/08/21 | Brandon United v Tow Law Town | 0 - 3 | Division 2 | 2021-22 | Welfare Ground | | 60 |
| Barry Smith (65 pen) Aaron Hardy (72) Jason White (76) |
| 2021-08-25 19:30:0025/08/21 | Ryton & Crawcrook Albion v Tow Law Town | 2 - 1 | Division 2 | 2021-22 | Kingsley Park | | 132 |
| Louis Anderson (17) Rhys McCleod (63) |
| Aaron Hardy (22) |
| 2021-08-28 15:00:0028/08/21 | Tow Law Town v Easington Colliery | 2 - 2 | Division 2 | 2021-22 | Ironworks Road | | 66 |
| Mason Hurworth (20), Michael Brown (37 pen) |
| Luke Page (11), Liam Adamson (47), , Ethan Ord sent off (70) |
| 2021-08-31 19:45:0031/08/21 | Carlisle City v Tow Law Town | 1 - 0 | Division 2 | 2021-22 | Gillford Park Stadium | | 97 |
| Aaron Bradbury (20 pen) |
| 2021-09-04 15:00:0004/09/21 | Newcastle University v Tow Law Town | 1 - 0 | Division 2 | 2021-22 | Kimberley Park | | 50 |
| Blake Wood (75) |
| Michael Brown sent off (12) |
| 2021-09-11 15:00:0011/09/21 | Willington v Tow Law Town | 3 - 2 | | 2021-22 | Hall Lane | FA VaseFirst Round Qualifying | 110 |
| Adam Storey 2 (44, 87) Ryan Cummings (62) |
| Liam Goldsbrough (27) Matty Moffatt (28) |
| 2021-09-18 15:00:0018/09/21 | Tow Law Town v Birtley Town | 3 - 1 | Division 2 | 2021-22 | Ironworks Road | | 80 |
| Drew Lake (4) Lewis Teasdale 2 (6, 39 pen), Barrie Smith missed pen (27) |
| James Norton (1) |
| 2021-09-21 19:30:0021/09/21 | Boldon CA v Tow Law Town | 1 - 1 | Division 2 | 2021-22 | Boldon Colliery Welfare Ground | | 121 |
| Daniel Wright |
| Drew Lake |
| 2021-09-25 15:00:0025/09/21 | Tow Law Town v Ryton & Crawcrook Albion | 2 - 1 | Division 2 | 2021-22 | Ironworks Road | | 72 |
| Lewis Teasdale (48) Drew Lake (65), Michael Brown sent off (78) |
| Rhys McLeod (72) |
| 2021-10-02 15:00:0002/10/21 | Washington v Tow Law Town | 0 - 1 | Division 2 | 2021-22 | Ford Hub Sports Complex | | 45 |
| Lewis Milner (57) |
| 2021-10-05 19:30:0005/10/21 | Tow Law Town v Willington [POSTPONED] | 19:30:007:30 pm | Division 2 | 2021-22 | Ironworks Road | | |
| 2021-10-09 15:00:0009/10/21 | Tow Law Town v Blyth Town | 1 - 0 | Division 2 | 2021-22 | Ironworks Road | | 90 |
| Darren Richardson (50) |
| 2021-10-16 15:00:0016/10/21 | Bedlington Terriers v Tow Law Town | 1 - 4 | Division 2 | 2021-22 | Doctor Pit Park | | 59 |
| Jordan Lashley (11) |
| Darren Richardson (36) John Jury (51) Alfie Pearl 2 (73, 90) |
| 2021-10-23 15:00:0023/10/21 | Tow Law Town v Horden CW | 1 - 1 | Division 2 | 2021-22 | Ironworks Road | | 61 |
| Aaron Hardy (27) |
| Liam Wright (87 pen) |
| 2021-10-29 19:30:0029/10/21 | Tow Law Town v Esh Winning | 19:30:007:30 pm | Division 2 | 2021-22 | Ironworks Road | | |
| 2021-11-06 15:00:0006/11/21 | Tow Law Town v Chester-le-Street | 15:00:003:00 pm | Division 2 | 2021-22 | Ironworks Road | | |
| 2021-11-13 15:00:0013/11/21 | Jarrow v Tow Law Town | 15:00:003:00 pm | Division 2 | 2021-22 | Perth Green CA | | |
| 2021-11-16 19:30:0016/11/21 | Tow Law Town v Durham City | 19:30:007:30 pm | Division 2 | 2021-22 | Ironworks Road | | |
| 2021-11-20 15:00:0020/11/21 | Tow Law Town v Sunderland West End | 15:00:003:00 pm | Division 2 | 2021-22 | Ironworks Road | | |
| 2021-12-04 15:00:0004/12/21 | Tow Law Town v Carlisle City | 15:00:003:00 pm | Division 2 | 2021-22 | Ironworks Road | | |
| 2021-12-18 15:00:0018/12/21 | Willington v Tow Law Town | 15:00:003:00 pm | Division 2 | 2021-22 | Hall Lane | | |
| 2022-01-08 15:00:0008/01/22 | Tow Law Town v Boldon CA | 15:00:003:00 pm | Division 2 | 2021-22 | Ironworks Road | | |
| 2022-01-15 15:00:0015/01/22 | Durham City v Tow Law Town | 15:00:003:00 pm | Division 2 | 2021-22 | Hall Lane | | |
| 2022-01-22 15:00:0022/01/22 | Redcar Town v Tow Law Town | 15:00:003:00 pm | Division 2 | 2021-22 | The Vibrant Stadium | | |
| 2022-01-29 15:00:0029/01/22 | Tow Law Town v Billingham Synthonia | 15:00:003:00 pm | Division 2 | 2021-22 | Ironworks Road | | |
| 2022-02-05 15:00:0005/02/22 | Heaton Stannington v Tow Law Town | 15:00:003:00 pm | Division 2 | 2021-22 | Grounsell Park | | |
| 2022-02-12 15:00:0012/02/22 | Tow Law Town v Brandon United | 15:00:003:00 pm | Division 2 | 2021-22 | Ironworks Road | | |
| 2022-02-19 15:00:0019/02/22 | Easington Colliery v Tow Law Town | 15:00:003:00 pm | Division 2 | 2021-22 | Welfare Park | | |
| 2022-02-26 15:00:0026/02/22 | Tow Law Town v Newcastle University | 15:00:003:00 pm | Division 2 | 2021-22 | Ironworks Road | | |
| 2022-03-12 15:00:0012/03/22 | Birtley Town v Tow Law Town | 15:00:003:00 pm | Division 2 | 2021-22 | The Arrowmark Home Improvements Stadium | | |
| 2022-03-19 15:00:0019/03/22 | Tow Law Town v Washington | 15:00:003:00 pm | Division 2 | 2021-22 | Ironworks Road | | |
| 2022-03-26 15:00:0026/03/22 | Blyth Town v Tow Law Town | 15:00:003:00 pm | Division 2 | 2021-22 | Gateway Park | | |
| 2022-04-02 15:00:0002/04/22 | Tow Law Town v Bedlington Terriers | 15:00:003:00 pm | Division 2 | 2021-22 | Ironworks Road | | |
| 2022-04-09 15:00:0009/04/22 | Horden CW v Tow Law Town | 15:00:003:00 pm | Division 2 | 2021-22 | Horden Community Welfare Park | | |
| 2022-04-16 15:00:0016/04/22 | Esh Winning v Tow Law Town | 15:00:003:00 pm | Division 2 | 2021-22 | The WindowsPlusRoofs Arena | | |
